Human Sera
Cayman Chemical Dydrogesteron 50mg
A synthetic progestin; has no estrogenic, androgenic, glucocorticoid, or anabolic effects; an agonist of progesterone receptors (EC50 = 12.3 nM); an antagonist of androgen, mineralocorticoid, and glucocorticoid receptors (IC50s = 28.6, 82.7, and 363 nM, respectively); protects against sound stress-induced abortion in mice at 1.25 mg per animal on day five of pregnancy
Cayman Chemical MosaprIdecItrate 50mg
A 5-HT4 agonist (Ki = 69.9 nM); selective for 5-HT4 over 5-HT1, 5-HT2, dopamine D2, and α1- and α2-adrenergic receptors at 1 mM but also acts as a partial antagonist at 5-HT3 (Ki = 1,189 nM); induces relaxation of precontracted rat esophageal thoracic muscularis mucosa preparations and enhances electrically evoked contractions in isolated guinea pig ileum (EC50s = 208.4 and 73.2 nM, respectively); increases antral and duodenal, but not ileal or colonic, motility in conscious dogs at 0.5 and 1 mg/kg; increases gastric emptying in rats from 0.03-30 mg/kg
Cayman Chemical DImethomorph 100mg
A morpholine fungicide; inhibits fungal cell wall formation; inhibits mycelial growth of the oomycete fungi P. citrophthora, P. parasitica, P. capsici, and P. infestans in vitro (EC50s = 0.14, 0.38, C. vulgaris or S. obliquus in vitro (EC50s = 47.46 and 44.87 UG/ml, respectively); inhibits AR activity in a reporter assay in MDA-kb2 human breast cancer cells, but not in a yeast antiandrogen screen (IC20s = 0.263 and 38.5 µM, respectively); not toxic to rats (LD50 = 3,900 mg/kg) or goldfish (C. auratus; LC50 = >32 UG/ml)
Bioss Estrogen Related Receptor gamm
Estrogen Related Receptor gamma Primary Antibody Unconjugated Host Species Rabbit Target Species Human Mouse Rat Clonality Monoclonal Applications WB RecombinantConcentration 1ug/ul Size 100 ul Storage Buffer 10mM phosphate buffered saline(pH 7 4) with 150mM sodium chloride 0 05% BSA 0 02% sodium azide and 50% glycerol
Cayman Chemical 1Pentadecnoylracglycerol 100mg
A monoacylglycerol; has been found in wheat bran extracts; levels are increased in a HepaRG cell-based model of hepatic steatosis induced by BSA-conjugated palmitate
Cayman Chemical SpIraprIlhydrochlorIde 50mg
An ACE inhibitor (IC50 = 67 nM) and a prodrug form of spiraprilat; inhibits the angiotensin I-induced pressor response in rats and dogs (ID50s = 16 and 262 UG/kg, respectively); decreases systolic blood pressure and left ventricular hypertrophy and induces angiogenesis in spontaneously hypertensive rats 5 mg/kg
Cayman Chemical 3methoxy TyramInhydroCLO 100mg
A natural metabolite of dopamine; a weak agonist of TAAR1 (EC50 = 1.7 µM)
Cayman Chemical Stva rbaudna sostvol 100mg
A diterpenoid with diverse biological activities; a hydrolysis product of stevioside; scavenges hydroxyl and superoxide radicals in cell-free assays (IC50s = 76.92 and 91.7 UG/ml, respectively); inhibits DNA polymerase α, β, and λ, as well as topoisomerase II (IC50s = 64, 177, 103, and 190 µM, respectively); active against various bacteria and fungi (MICs = 8-250 and 62.5-500 UG/ml UG/ml ,respectively); induces relaxation of isolated rat aortic strips precontracted with vasopressin, an effect that can be reversed by glibenclamide or apamin but not charybdotoxin; reduces plasma glucose levels in the intravenous glucose tolerance test in Zucker diabetic rats at 5 and 10 mg/kg; has been used in the synthesis of isosteviol glycosides with anticancer activity
Cayman Chemical ClofentezIn 100mg
An acaricide; has broad-spectrum activity against various plant-feeding mite species; lethal to wild-type, but not chs1 mutant, T. urticae mite eggs (LC50s = 1.2 and >5,000 mg/L, respectively); induces formation of thyroid tumors in male rats from 13-1,000 mg/kg per day
Cayman Chemical Epmed folum Epmedn C 50mg
A flavonoid glycoside; scavenges DPPH radicals in a cell-free assay (IC50 = 142 µM); increases proliferation of UMR-106 osteoblasts by 30.4 and 41.6% at 0.1 and 10 µM, respectively; inhibits TPA-induced EAr edema in mice (ED50 = 192 nmol/ear)
Cayman Chemical DapnsutrIle 100mg
An NLRP3 inflammasome inhibitor; inhibits the release of IL-1β and decreases caspase-1 levels in LPS-stimulated J774A.1 murine macrophages, HMDMs, and primary human blood neutrophils; selective for NLRP3 over NLRP4 and AIM2 inflammasomes at concentrations up to 100 μM; inhibits ASC oligomerization and NLRP3 association with caspase-1 and ASC in LPS- and nigericin-stimulated J774A.1 cells; reduces MPO, CXCL1, and IL-6 levels in peritoneal fluid as well as IL-1β levels in liver, lung, spleen, and skeletal muscle in a mouse model of LPS-induced systemic inflammation; increases markers of oxidative metabolism in muscle in mouse model of LPS-induced systemic inflammation; reduces IL-1β release in blood monocytes isolated from patients with CAPS
Cayman Chemical 5a-ndrostn-3-ol 50mg
A steroidal androgen; binds to the androgen receptor in a cell-free assay (IC50 = 1.7 µM); activates PXR in HepG2 cells in a reporter assay (EC50 = 0.8 µM); inhibits the androst-4-ene-3,17-dione hydroxylase activities of 16α- and 6β-hydroxylase but not 16β- or 7α-hydroxylase (IC50s = 70, 110, >150, and >150 µM, respectively); decreases testis weight and sperm production in mice at 30 mg/kg
Cayman Chemical S-5-FluorowIlardIIn 100mg
An agonist of GluA1 and GluA2; selectively activates GluA1 and GluA2 over GluA3 and GluA4 in voltage-clamp assays using X. laevis oocytes expressing the flip isoforms of the rat receptors (EC50s = 0.382, 0.463, 20.9, and 11.9 µM, respectively); induces evoked population spikes in isolated rat CA1 hippocampal slices in an in vitro model of seizure-like activity (EC50 = 0.03-0.08 µM)
Cayman Chemical D-Mnose-6-PhosphatesodIum 50mg
A phosphorylated aldohexose that can be used to produce glucose, mannitol, or N-glycans; also a ligand for both cation-dependent and -independent receptors and binds, as part of an N-glycan, to MRH domains on other proteins